Objectives:
The aim of this course is to cover the evolutionary and developmental processes leading to the formation of the central and peripheral nervous systems (from their tissue origin to the establishment of functional neuronal networks). We will then look at the pathologies associated with alterations in these processes, making the link between molecular and cellular mechanisms, dysfunctional circuits and the observed clinical phenotype. Finally, we will look at animal models and therapies currently available or under evaluation.
Appearance and complexity
in the evolution of the nervous system :
In search of the first neurons/ From a diffuse nervous system to centralization
Appearance of the different tissues making up the nervous system
Motor/sensory, somatic/visceral duality
Development of the central nervous system in mammals
Axonal growth and establishment of synapses
Establishment of the functional network
Notion of critical period for the onset of disorders
Development of circuits involved in neurodevelopmental disorders: the case of emotional disorders
Definition (DSM5/developmental gradient)- Similarities and differences- Impact on synaptogenesis and the establishment of functional networks
Etiologies, Neuroanatomical and cellular substrates, Preclinical models
Etiologies, Neural substrates of adolescent behavioral changes, Preclinical models and treatments
Epilepsy
Neuropsychological assessment and new therapies (the case of serious games)
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Français
English