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UE28 Biochimie structurale

ECUE's code : SMUSVI28

This course give 6.0 ECTS.
EUR LIFE
Biochimie et biologie moléculaire
Campus Valrose
Master 1 , Master 2
Semestre impair
Anglais

PRESENTATION

This module will introduce you to the main concepts of structural biochemistry.

We'll cover experimental

  •     techniques,
  •     biophysics,
  •     structural bioinformatics
  •     molecular modeling (homology modeling, drug design, molecular dynamics),

In addition, we will study examples of macro-molecular assemblies and their dynamics.

Course's manager(s)

Romain Gautier

In class

  • 22h of lectures
  • 10h of directed studies
  • 10h of practical work

PREREQUISITES

Before the start of the course, I must ...
  • use of the molecular visualization tool (Pymol)
  • analyze biological sequences,
  • master the biochemistry of proteins and membranes,

OBJECTIVES

By the end of this course, I should be able to...
  • Carry out a molecular modeling project, starting with a structural study of a protein sequence and proposing a structural model using bioinformatics tools such as homology modeling.

CONTENT

  • 1- Introduction Structural biochemistry, 24h

    Analysis and prediction tools / structure
    On-machine practical work (bioinformatics tools, Pymol)
    Basics of molecular modeling
    Case study of homology modeling

    R. Gautier (MC, IPMC)

  • 2- Biophysical techniques, 10h

    G. Drin (DR CNRS, IPMC)

     

  • 3- Macro-molecule assembly, 4h

    L. Counillon (PR, LP2M)

  • 3h final exam with documents (2 subjects) and a molecular modeling project (structural study of a protein sequence with proposal of a structural model using bioinformatics tools such as Homology Modeling).

     

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Important
This syllabus has no contractual value. Its content is subject to change throughout this year: be aware to the last updates